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Mettler-Toledo AG

Joining Two Flow Chemistry Technologies Benefits Synthetic Chemists

Thursday, 23 August 2012


GREIFENSEE (CH) - METTLER TOLEDO announced publication of a new white paper entitled “Rapid Analysis of Continuous Reaction Optimization Experiments: Vapourtec R-SeriesTM and METTLER TOLEDO FlowIRTM Integration.” 

This entry in the extensive collection of thought-leadership resources from METTLER TOLEDO demonstrates the value of FlowIR™  - an inline, non-destructive method of rapidly accessing reaction optimization data and accurately mapping dispersion curves, along with the value of integrating data from FlowIR™ with Vapourtec Flow CommanderTM software. The collaboration gives users a greater insight into their chemistry, and the improved data integration enables the automatic triggering  of the collection of the optimum fraction within a reaction plug  as measured in situ by FlowIR™. The result is the kind of time-savings that are critical to staying ahead in today’s fast-paced global manufacturing marketplace.

The paper highlights two examples where FlowIR™ was used as the key inline diagnostic tool to quickly and easily optimize reaction conditions by viewing in situ the effects of changing process variables (residence time, temperature, stoichiometry etc). The synthetic chemistries profiled were chosen because of the challenges inherent in analyzing them using standard offline techniques.

The first example, The Doebner Modification of the Knoevenagel Condensation Reaction, provided an ideal example to optimize using Fourier Transform Infrared (FTIR) spectroscopy because it is difficult to follow by standard laboratory Liquid Chromatography (LC) methods as it involves a lengthy work-up.

In the second example, a One Step Synthesis of Substituted Indazoles, a number of intermediates are formed under mild conditions. Having an in situ tool allows these to be followed by their unique IR profile and enables the easy optimization of this type of chemistry.

For both chemistries, profile data from FlowIR™ was logged and displayed in real time within Vapourtec Flow Commander™ software – a benefit users of FlowIR™ can now enjoy due to tighter integration between the two systems thanks to the ongoing collaboration between METTLER TOLEDO and Vapourtec.

METTLER TOLEDO experts note that as multi-step sequences and downstream processing become more common, in situ analysis techniques such as the one represented by the METTLER TOLEDO-Vapourtec collaboration will continue gaining in importance.

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